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KMID : 1160220230510040256
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Mycobiology
2023 Volume.51 No. 4 p.256 ~ p.263
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Comparative Analysis of Anticancer and Antibacterial Activities among Seven Trametes Species
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Ha Thi Kim Nguyen
Lee Ji-Won
Park Ye-Jin
Park Hyon-Jin
Ahn Soon-Kil
Kim Jae-Kwang
Kang Dong-Ku
Kim Min-Kyeong
Ahn Cho-Rong
Kim Chang-Mu
Choi Jae-Hyuk
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Abstract
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Species in the genus Trametes (Basidiomycota, Polyporales) have been used in natural medicinefor a long time. Many studies reported that mycelia or fruiting bodies of Trametes spp.
exhibited effects of antioxidant, anti-inflammatory, anticancer, and antimicrobial activities.
However, comparative analysis in this genus is scarce due to limitation of morphologicalidentification and the sample number. In this study, the 19 strains of seven Trametes specieswere chosen to generate a five-gene-based phylogeny with the 31 global references. In addition,39 culture extracts were prepared for 13 strains to test for anticancer and antibacterialactivities. Strong anticancer activities were found in several extracts from T. hirsuta and T.
suaveolens. Anticancer activities of T. suaveolens, T. cf. junipericola and T. trogii were firstdescribed here. The antibacterial ability of T. versicolor and T. hirsuta extracts has been confirmed.
The antibacterial activities of T. suaveolens have been reported at the first time inthis study. These results suggest an efficient application of the genus Trametes as the drugresources especially for anticancer agents.
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KEYWORD
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Trametes, anticancer, antibacterial, antitumor, antimicrobial
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