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KMID : 1160619970020010029
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Preventive Nutrition and Food Science
1997 Volume.2 No. 1 p.29 ~ p.34
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Antimutagenic Effects of Linoleic Acid
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Lim Sun-Young
Rhee Sook-Hee
Park Kun-Young
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Abstract
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In order to determine the effectiveness of linoleic acid(LA) to inhibit carcinogens/mutagens-induced mu-tagenesis, Ames test using Salmonella typhimurium TA100 and the SOS chromotest using E. Coli PQ37, were carried out. The inhibitory effect of LA(1%) on the Ames mutagenicity test were 98%, 78%and 69% mediated by aflatoxin B₁(AFB₁), N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and 4-nitroquinoline-1-oxide(4-NQO), respectively. LA exhibited a strong antimutagenic activity aganist indirect mutagen, AFB₁whereas exhibited the same concentration of LA showed weaker inhibitory effects on direct mutagens of MNNG and 4-NQO than that AFB₁. LA also reduced the SOS responses induced by MNNG and 4-NQO significantly. This result showed a possibility that LA can be a protective agent in early step of cancinogenesis.
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KEYWORD
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linoleic acid(LA), Ames test, SOS chromotest, antimutagenicity
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