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KMID : 1160619970020030236
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Preventive Nutrition and Food Science
1997 Volume.2 No. 3 p.236 ~ p.240
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Inhibition of Hepatocellular Carcinoma Cell Growth by the Extract of Symphytum offcinale L. and the Possible Mechanisms for this Inhibition
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Ham Seung-Shi
Choi Kyong-Gun
Lee Yong-Moon
Lee Young-Ik
Yoon Ji-Won
Kim Seong-Jin
Lee Deuk-Sik
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Abstract
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A crude extract of Smphytum officinale L. (comfrey) was for its ability to inhibit he growth of hepatocellular carcinoma cells and expression of the insulin-like growth factor I (IGF-II) gene. The DNA synthesis of hepatocellular carcinoma cell lines, Hep G2, Hep 3B, and PLC/PRF/5 was inhibited by a crude extract of Smphytum officinale in both a time- and a dose-dependent manners. This plant extract also inhibited expression of the IGF-II gene. Since IGF-II exerts a mitogenic effect on Hep G2 cells, these results suggest that the growth inhibition by Symphytum officinale extract is, in part, mediated through the inhibition of IGF-II gene expression.
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KEYWORD
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Symphytum officinale L. extract, insulin-like growth factor II, growth inhibition, gene expression
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