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KMID : 1160619970020030241
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Preventive Nutrition and Food Science
1997 Volume.2 No. 3 p.241 ~ p.245
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Inhibitory Effects of Kimchi Extracts on Carcinogen-induced Cytotoxicity and Transformation in C3H/10T1/2 Cells
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Choi Moung-Won
Kim Kwang-Hyuk
Kim So-Hee
Park Kun-Young
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Abstract
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Inhibitory effects of kimchi extracts on arcinogen-induced cytotoxicity and transformation in C3H/10T1/2 cells were studied. The methanol extract (500㎍/ml) of fresh (unfermented kimchi), and 3-week-fermented kimchi (properly ripened kimchi at 5℃) inhibited 3-methylcholanthrene (MCA)-induced cytotoxicity in C3H/10T1/2 cells by 84 and 99%, respectively. The inhibitory effect of 3-week-fermented kimchi was higher than that of the fresh kimchi at same test condition. The methanol soluble fraction, and haxane extract of 3-week fermented kimchi also surpressed the cytotoxicity of FC3H/10T1/2 cells mediated by 7,12-dimethylbenz[a]anthracene(DMBA) and N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). Furthermore, MCA-induced transformation of C3H/10T/1/2 cells was significantly inhibited by the methanol soluble fraction of 3-week fermented kimchi. With these results, we suggest that kimchi might have anticarcinogenic effect in part due to inhibition of carcinogen-induced cytotoxicity and transformation of C3H/10T/1/2 cells.
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KEYWORD
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kimchi, C3H/10T1/2 cells, cytotoxicity, transformation
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