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KMID : 1160619990040030188
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Preventive Nutrition and Food Science
1999 Volume.4 No. 3 p.188 ~ p.192
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Effects of Methanol Extract of Prosomillet on Cholesterol and Fatty Acid Metabolism in Rat
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Cho Sung-Hee
Jung Seung-Eun
Lee Hye-Kyung
Ha Tae-Youl
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Abstract
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To study effects of methanol extract of prosomillet on lipid metbolism, five groups of male Sprague-Dawley rats weighing 116±9 g were fed test diets for four weeks. The five diets consisted of one low fat (5% w/w) diet containing starch as carbohydrate source (normal) and four high fat diets (15% w/w) containing 40.5% (w/w) sucrose (control) and additional 80% methanol extract of prosomillet at the levels of 0.3% and 1 % (w/w) or prosomillet powder at the level of 20% (w/w). Serum level of total cholesterol was a little higher but that of triglyceride was 41 % lower in 20% (w/w) prosomillet powder group than in the control group. The cholesterol levels of two groups fed methanol extract were not different from the control but their triglyceride levels tended to be reduced. Liver cholesterol levels were lower and phospholipid levels higher in all three prosomillet groups than the control but triglyceride level was significantly low only in the prosomillet powder group. Fecal excretion of bile acid was most increased in the prosomillet powder group among all five test groups. Activity of liver microsomal 3hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase was significantly lower in 0.3% methanol extract fed group than the control and also appeared to be reduced in 1 % extract fed one, whereas those of 20 cholesterol 7a-hydroxylase were not different among the five groups. Activities of liver cytosolic glucose-6-phosphate dehydrogenase (G6PDH) and malic enzyme were decreased in 0.3% prosomillet methanol extract and 20% powder groups. The results indicate that in addition to fiber, certain active components in prosomillet have potential to exert hypolipidemic effects via regulating hepatic cholesterogenesis and lipogenesis.
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KEYWORD
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prosomillet, hypolipidemic effect, HMG CoA reductase, G6PDH, malic enzyme
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