|
KMID : 1160620000050010037
|
|
Preventive Nutrition and Food Science
2000 Volume.5 No. 1 p.37 ~ p.41
|
|
|
Effects of Ethylacetate Fraction of Persimmon Leaves on Experimentally-induced Gastric Mucosal Damage and Gastric Ulcers in Rats
|
|
Choo Myung-Hee
Choi Hyun-Suk
Shin Kil-Man
Jung Soon-Teck
Kim Kyong-Su
Lee Myung-Yul
|
|
|
Abstract
|
|
|
|
The protective effects of the ethylacetate fraction of persimmon leaves(PEF) against experimentally induced gastric mucosal damage and gastric ulcers were evaluated in ratss. In prophylatic study, 100 mg/kg ethylacetate fraction of persimmon leaves (PEFH) exhibited a total protection of 73.8% and 65.7% against HCl-ethanol and 0.2N NaOH-induced gastric mucosal membrane lesions, respectively, which was superior to cimetidine 50 mg/kg, a commonly used anti-ulcer drug. PEFH showed excellent anti-ulcer effects against pylorus ligation induced gastric ulcers, compared to the control group, however, 50 mg/kg ethylacetate fraction of persimmon leaves (PEFL) and PEFH did not affect ulcers induced by water immersion stress, and that is inferior to cimetidine 50 mg/kg. In conclusion, the results suggest that the ethylacetate fraction of persimmon leaves can be used both in prevention and treatment of experimentally induced gastric mucosal damage and ulcers.
|
|
|
KEYWORD
|
|
|
persimmon leaves, ethylacetate fraction, prevention and treatment, HCl-ethanol, water immersion stress, gastric ulcer, mucosal damage
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|