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KMID : 1160620000050030170
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Preventive Nutrition and Food Science
2000 Volume.5 No. 3 p.170 ~ p.173
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Inhibitory Effects of Various Edible Plants and Flavonoids from the Leaves of Cedrela sinensis on Human Immunodeficiency Virus Type 1 Protease
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Park Jong-Cheol
Hur Jong-Moon
Park Ju-Gwon
Kim Hyun-Joo
Kang Kyeong-Hee
Park Myeong-Rak
Song Sang-Ho
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Abstract
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The inhibitory effect of extracts from 15 edible plants on the protease of human immunodeficiency virus (HIV) type 1 was investigated. Protease activity was determined by incubating the extracts in a reaction mixture containing protease and substrate His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 to inhibit proteolytic cleavage. Of various plants tested, the leaves of Cedrela sinensis inhibited the HIV-1 protease by 42% at a concentration of 100μg/ml. A major flavonoid isolated from the leaves of C. sinensis, quercetin 3-O-α-L-rhamnoside showed inhibitory activity of 19% at a concentration of 100μM.
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KEYWORD
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HIV-1 protease, protease inhibitor, edible plant, Cedrela sinensis, flavonoid
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