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KMID : 1160620010060010038
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Preventive Nutrition and Food Science
2001 Volume.6 No. 1 p.38 ~ p.42
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Rats Lens Aldose Reductase Inhibitor Activities of Leguminous Seed Extracts
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Kim Byung-Su
Kim Min-Jeong
Kim Hye-Young
Ahn Young-Joon
Lee Hoi-Seon
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Abstract
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The methanol extracts of 25 leguminous seeds in vitro were evaluated for inhibitory activities against lens aldose reductase of Sprague Dawley male rats. The responses varied with both leguminous seed and concentration used. At the concentration of 0.1 ㎎/mL, the methanol extracts from Amphicarpaea edgeworthii, Canavalia lineata, Glycine max var. solitae, Glycine max var. yagkong, Glycine max var. hooktae, Glycine max var. bangkong, Glycine max var. geumdu, Glycine max var. chungtae, Glycine max var. mejukong, Glycine soja, Phaseolus radiatus var. geodu, Vicia tetrasperma, Vigna angulasis, and Vigna sinensis inhibited enzyme activity by greater than 60%. In following study, at the concentration of 0.01 ㎎/mL, the extracts of C. lineata and V. tetrasperma had relatively strong inhibitory activity against aldose reductase. Because of their potent inhibitory activities, the activity of each solvent fraction from C. lineata and V. tetrasperma was determined, and the potent activity was showed from chloroform and hexane fractions, respectively. IC_(50) values of C. lineata and V. tetrasperma were 0.004 and 0.006 ㎎/mL, respectively. As a naturally occurring therapeutic agent, leguminous seeds described could be useful for developing new agents of antidiabetic complications.
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KEYWORD
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legume, lens aldose reductase, Canavalia lineata, Vicia tetrasperma
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