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KMID : 1160620010060010051
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Preventive Nutrition and Food Science
2001 Volume.6 No. 1 p.51 ~ p.56
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Effects of Antioxidant Nutrient Supplementation on the Lipid Peroxidation and Antioxidative Enzyme Activities in Patients with Coronary Heart Disease
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Joung Hyo-Jee
Chun Byung-Yeol
Choi Young-Sun
Kim Su-Eun
Park Wee-Hyun
Jun Jae-Eun
Chae Shung-Chull
Song Kyung-Eun
Cho Sung-Hee
Oh Hee-Sook
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Abstract
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This study was carried out to evaluate whether antioxidant nutrient supplementation with α-tocopherol, vitamin C, β-carotene, and selenium reduces the lipid peroxide levels and increases the anti oxidative enzyme activities in patients with coronary heart disease. Eighty nine patients participated in a randomized, double-blind, placebo-controlled trial. The antioxidant group (45 patients) was given daily doses of α-tocopherol (400 IU), vitamin C (50 ㎎), β-carotene (15 ㎎), and selenium (50 ㎎) and forty four patients received a placebo. Thirty eight subjects (84.4%) of the antioxidant group and thirty nine subjects (88.6%) of the placebo group completed the three-month supplementation. Serum levels of tocopherol, vitamin C and β-carotene significantly increased in the antioxidant group compared with the baseline (p<0.05). Thiobarbituric acid-reactive substances (TBARS) decreased significantly (0.6 n㏖ MDA/mL) in the antioxidant group compared with that (0.09 n㏖ MDA/mL) in the placebo group (p=0.03). However, antioxidant supplementation did not affect the level of oxidized-LDL measured as autoantibodies against oxidized-LDL. The superoxide dimutase activity in red blood cells increased in the antioxidant group compared with the baseline (p<0.05). However, glutathione peroxidase activities did not change after supplementation in both groups, and catalase activity significantly decreased in the placebo group (p<0.05). These results suggest that antioxidant supplementation for 3 months with α-tocopherol, vitamin C, β-carotene and selenium in patients with coronary heart disease may be partially protective against oxidative stress.
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KEYWORD
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antioxidant nutrient, coronary heart disease, lipid peroxidation, antioxidative enzyme, randomized controled clinical trial
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