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KMID : 1160620010060020122
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Preventive Nutrition and Food Science
2001 Volume.6 No. 2 p.122 ~ p.125
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Comparison of Jujube Extract with Tangerine Peel Extract in Lowering Plasma Lipids and Activities of Cholesterol Regulating Enzymes in Cholesterol-Fed Rats
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Park Myung-Sook
Bok Song-Hae
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Abstract
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A potential mechanism through which the jujube extract might produce a cholesterol-lowering effect was compared with that of tangerine peel extract in vivo. Two extracts were prepared using ethanol. Male rats were fed a high cholesterol (1%, w/w) lab chow with jujube extract (1.2%, w/w) or tangerine peel extract (6.3%, w/w) for 3 weeks. Activities of hepatic HMG-CoA reductase (289.6±12.9 and 296.7±11.6 nmole/min/㎎ vs. 347.9±17.5 nmole/min/㎎) and ACAT (554.8±18.2 and 451.7±19.4 nmole/min/㎎ vs. 602.6±21.4 nmole/min/㎎) were significantly lowered by both supplements compared to the control group. These two supplements also substantially reduced the concentrations of plasma cholesterol (103.3±15.9 and 101.6±19.4 ㎎/dL vs. 141.6±18.1 ㎎/dL) and triglyceride (61.3±5.5 and 55.5±3.9 ㎎/dL vs. 96.0±4.2 ㎎/dL). The inhibition of HMG-CoA reductase resulting from the supplementation of jujube or tangerine extracts could count for the reduction in plasma cholesterol. Accordingly, lipid-lowering action of both supplements appears to be similar in high-cholesterol fed rats.
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KEYWORD
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high-cholesterol diet, jujube, HMG-CoA reductase, ACAT, tangerine peel extract
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