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KMID : 1160620010060020126
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Preventive Nutrition and Food Science
2001 Volume.6 No. 2 p.126 ~ p.132
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Effects of Kimchi Extracts on Production of Nitric Oxide by Activated Macrophages, Transforming Growth Factor
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Kim Kwang-Hyuk
Kim So-Hee
Park Kun-Young
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Abstract
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Methanol extracts from four kinds of kimchi, which were differently prepared in kinds and levels of sub-ingredients, were given to Balb/c mice for 3 weeks (0.5 ㎎/㎏/day). Peritoneal macrophages isolated from mice treated with kimchi extracts and saline were stimulated by lipopolysaccharide (LPS). K3 and K4 kimchis, containing more red pepper powder, garlic, Chinese pepper powder, mustard leaf and organically cultivated Korean cabbage, siginificantly increased NO production by the activated macrophages (p<0.05). K1, K2, K3 and K4 kimchi extracts (0.01, 0.1, 1.0 ㎍) significantly reduced the increased TGF-β1 production of H. pylori lysate (0.01 ㎍)-activated human epithelial RPMI 2650 cells (5×10⁴ cells/mL) at 24 and 48 hrs of treatment (p<0.01). However, the decreased TGF-β1 α production of RPMI 2650 cells by H. pylori lysate increased by treatment with kimchi extract for 72 hrs. Especially, K4 kimchi (containing organically cultivated Korean cabbage and more ingredients, modulated TGF-β1 production of H. pylori lysate-activated RPMI 2650 cells to the normal level (control) by treatment for 48 hrs. The treatment of K1 and K4 kimchi enhanced the LPS (0.01 ㎍/mL)-induced IL-6 production of splenocytes. The results suggest that kimchi might have an beneficial effect on cancer prevention due in part to the function enhancing NO production of activated macrophages. Our data suggest that kimchi could modulate TGF-β1 production by cancer cells and IL-6 production of splenocytes, thereby possibly contributing to control carcinogenesis and the immune system.
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KEYWORD
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kimchi, TGF-β1 productionl, NO production, antitumor effect
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