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KMID : 1160620020070040347
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Preventive Nutrition and Food Science
2002 Volume.7 No. 4 p.347 ~ p.352
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Anti-rheumatoidal Effect of Sulfuretin Isolated from the Heartwood of Rhus veniciflua in Rats and Mice
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Choi Jong-Won
Yoon Byung-Jae
Huh Keun
Park Kun-Young
Lee Kyung-Tae
Park Hee-Juhn
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Abstract
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The present study was undertaken to evaluate the anti-rheumatoidal arthritis effect of the R. verniciflua heartwood extract, its EtOAc fraction, and its primary flavonoids, sulfuretin and fustin. All test samples showed variably significant inhibitory effects on hind paw edema and trypsin inhibitor activity induced by Freund's complete adjuvant reagent (FCA reagent), and on vascular permeability caused by acetic acid. Treatment with 10 mg/kg (i.p.) sulfuretin for seven days inhibited edema formation by 54.2±3.0%. Test samples, especially sulfuretin, shifted the values of biochemical parameters such as serum-cholesterol, serum-triglyceride and serum-total protein toward the normal and restored the numbers of leucocytes and platelets. These results suggest that the heartwood of R. verniciflua reduces immunological injuries caused by FCA reagent provides evidence that suluretin is an active anti-rheumatoid arthritis agent.
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KEYWORD
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Rhus verniciflua, sulfuretin, anti-rheumatoid arthritis
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