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KMID : 1160620020070040358
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Preventive Nutrition and Food Science
2002 Volume.7 No. 4 p.358 ~ p.366
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Induction of Quinone Reductase, an Anticarcinogenic Marker Enzyme, by Medicinal Herb Extracts
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Kwon Chong-Suk
Kim Ji-Hyeon
Son Kun-Ho
Kim Young-kyoon
Lee Jeong-Soon
Lim Jin-Kyu
Kim Jong-Sang
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Abstract
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To search for novel cancer preventive agents, we assessed the quinone reductase (QR)-inducing activities of medicinal herb extracts in cultured murine hepatoma cells (hepa1c1c7 cells). Among 216 herb extracts tested in this study, 8 kinds of herbal extracts were found to induce QR activity in hepa1c1c7 cells by more than 2-fold when used at the concentration of 25 g/mL. The methanol extracts of Aster koraiensis NK and Pulsatilla koreana Nakai induced QR by 252 and 223%, respectively, at the concentration of 25 g/mL. Most of the herbal extracts with QR inducing-activity increased the enzyme activity in a typical dose-dependent manner. The QR activity in BPrc1 cells was induced more than 50% by the extracts of Pulsatilla koreana Nakai, Inula helenium, Physalis alkekengi var. francheti (Masters) Makino, Chrysanthemum zawadskii var. latilobum Kitamura, Artemisia keiskeana Miquel, Chrysanthemum boreale Makino. In conclusion, Pulsatilla koreana Nakai, Aster koraiensis N.K, and Chrysanthemum zawadskii var. latilobum Kitamura, which showed relatively high QR induction, merit further animal study to evaluate their potential as cancer preventive agents.
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KEYWORD
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medicinal herb, quinone reductase, cancer prevention, hepa1c1c7, BPrc1
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