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KMID : 1160620020070040447
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Preventive Nutrition and Food Science
2002 Volume.7 No. 4 p.447 ~ p.450
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Inhibition of Tyrosinase and Lipoxygenase Activities by Resveratrol and Its Derivatives from Seeds of Paeonia lactiflora
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Kim Hyo-Jin
Ha Sang-Chul
Park Sang-Won
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Abstract
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Previously, a methanol extract from seeds of Paeonia lactiflora was shown to have a potent inhibitory activities against tyrosinase and soybean lipoxygenase (SLO). Seven stilbenes, trans-resveratrol-4-O-β-D-glucoside, trans-ε-viniferin resveratrol, trans-ε-viniferin, cis-ε-viniferin, gnetin H, suffruticosol A and B were isolated from the seeds as active principles for inhibition of the enzymatic activity. Among them, the resveratrol trimer, gnetin H exhibited the most potent inhibitory activities against tyrosinase and SLO, respectively. Additionally, the resveratrol dimers, trans-ε-viniferin and cis-ε-viniferin exhibited significant inhibitory activity against the two oxidative enzymes. Meanwhile, three other stilbene derivatives, such as trans-resveratrol, suffruticosol A and suffruticosol B had also weak inhibition activity. The least inhibitory activity was observed in trans- resveratrol-4-O-β-D-glucoside. These results suggest that resveratrol dimers and trimer in the seeds of Paeonia lactiflora are potentially useful therapeutic agents against pathological disorders such as hyperpigmentation and inflammation.
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KEYWORD
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Paeonia lactiflora Pall., Paeoniaceae, tyrosinase, soybean lipoxygenase, stilbene derivatives
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