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KMID : 1160620030080010001
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Preventive Nutrition and Food Science
2003 Volume.8 No. 1 p.1 ~ p.6
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(+)-Catechin is a Potent Inhibitor of Intestinal Absorption of Cholesterol in Rats
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Noh Sang-K.
Koo Sung-I.
Jiang Yongzhi
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Abstract
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Catechins exhibit a hypocholesterolemic effect in cholesterol-fed animals. The present study was conducted to examine whether (+)-catechin influences the absorption of cholesterol in rats. Male Sprague-Dawley rats were fed ad libitum an AIN-93G diet containing soybean oil for 5 wk. Rats with lymph cannulae were infused at 3.0 mL/h for 8 h via a duodenal catheter with a lipid emulsion containing radiolabeled cholesterol with or without (+)-catechin. Lymph was collected hourly for 8 h. The enteral infusion of (+)-catechin significantly lowered the lymphatic absorption of 14 C-cholesterol (21.1 ± 3.6% dose/B h) compared with controls infused with the lipid emulsion devoid of (+)-catechin (38.2 ± 1.2% dose/8 h). The intestinal absorption of α-tocopherol (24.2±3.0% dose/8 h) also was significantly decreased by (+)-catechin infusion, relative to controls (32.2±2.2% dose/8 h). However, the lymphatic outputs of oleic acid and phospholipid were not affected by enteral (+)-catechin infusion. The results indicate that (+)-catechin has a profound inhibitory effect on the intestinal absorption of cholesterol and α-tocopherol without affecting the absorption of fat.
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KEYWORD
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(+)-catechin, cholesterol, fat, intestinal absorption, α-tocopherol
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