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KMID : 1160620030080020141
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Preventive Nutrition and Food Science
2003 Volume.8 No. 2 p.141 ~ p.144
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Inhibition of Monamine Oxidase by a Flavone and Its Glycoside from Ixeris dentata Nakai
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Chung Ha-Sook
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Abstract
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Ixeris dentata Nakai (Compositae) is a perennial herb which has been used as a folk medicine for treating diabetes and gastroenteric troubles in Korea. Active compounds were isolated from the aerial parts of Ixeris dentata through the bioassay-guided fractionation and isolation method evaluated for inhibition of monoamine oxidase (MAO) in vitro. The compounds were identified as 5,7,3',4'-tetrahydroxyflavone (1) and 5,7,3',4'- tetrahydroxyflavone 7-glucoside (2), based on physical and spectroscopic characteristics. Compounds 1 and 2 showed a selective inhibition of type B MAO (MAO-B) activity, with IC/sub 50/ values of 15.3 μM and 36.4 μM, respectively, but did not inhibit type A MAO (MAO-A) activity.
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KEYWORD
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monoamine oxidase, Ixeris dentata Nakai, flavone, luteolin, cynaroside
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