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KMID : 1160620030080030289
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Preventive Nutrition and Food Science
2003 Volume.8 No. 3 p.289 ~ p.293
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Antioxidant and Nicotine Degradation Effects of Medicinal Herbs
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Lee Ho-Jae
Hur Sung-Ho
Shin Eui-Cheol
Lee Yang-Bong
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Abstract
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Antioxidant activity and nicotine degradation activity (NDA) of 21 medicinal herbs were determined by using a 1,1-diphenol-2-picrylhydrazyl (DPPH) method and a PLC/PRF5 human liver cell line method, respectively, to develop an anti-smoking aid. The highest and lowest antioxidant activities represented by IC50/ value were 30 ㎍/mL of Eugenia caryophyllus and 3,270 ㎍/mL of Panax ginseng C. A. Meyer, respectively. Antioxidant activity of Eugenia caryophyllus was equal to 38.0±1.2 mg VCEAC(vitamin C equivalent antioxidant capacity)/ g herb. The highest and lowest NDA values were 1.81 of Astrgalus membranaceus Bunge and 1.01 of Raphani seed and Lespedeza tomentosa Sieb, respectively. Eleven medicinal herbs with high antioxidant activity and/or NDA were selected to make an herbal tea. The herbal tea had high antioxidant activity (50 ㎍/mL IC50/ and 22.4±1.4 mgVCEAC/g) and NDA (1.243). The medicinal herb tea could help smokers quitting smoking by degrading and exhausting nicotine accumulated in body and removing reactive oxygen species.
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KEYWORD
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quit smoking, antioxidant, nicotine degradation activity, cotinine, medicinal herb
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