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KMID : 1160620040090030265
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Preventive Nutrition and Food Science
2004 Volume.9 No. 3 p.265 ~ p.269
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Cytotoxic Effect of Fruit of Prunus mandshurica on Human Monocytic Leukemia Cells
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Chung Ha-Sook
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Abstract
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Prunus mandshurica var. glabra Nakai (Rosaceae) is widely distributed in South Korea and bears a fruit with a bitter and astringent taste. An ethyl acetate-soluble extract of Prunus mandshurica was found to exhibit significant cytotoxicity against human leukemia cell lines. Bioassay-directed fractionation of this extract using an MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cell proliferation assay as a monitor led to the isolation of the bioactive compounds. Two compounds, 1 and 2 were subsequently found to mediate cytotoxicity against U937, human monocytic leukemia cells. The 50% growth inhibitory concentrations (IC_(50)) of compounds 1 and 2 on U937 were 40 and 62 μg/mL, respectively.
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KEYWORD
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Prunus mandshurica, flavonoid, cytotoxicity, human monocytic leukemia cells
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