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KMID : 1160620050100030239
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Preventive Nutrition and Food Science
2005 Volume.10 No. 3 p.239 ~ p.243
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Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Elk (Cervus elaphus) Velvet Antler
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Karawita Rohan
Park Pyo-Jam
Siriwardhana Nalin
Jeon Byong-Tae
Moon Sang-Ho
Ahn Duk-Kyun
Cho So-Mi K.
Jeon You-Jin
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Abstract
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Angiotensin I-converting enzyme (ACE) inhibitory activities of elk antler hydrolysates prepared with three kinds of proteases, pepsin, trypsin and α-chymotrypsin, were investigated. The ACE inhibitory activity of the pepsinolytic hydrolysate was the highest with an IC_(50) value of 9.3 ㎍/mL. In addition, three kinds of pepsinolytic hydrolysates with relatively high molecular weights (over 10,000 Da), medium molecular weights (5,000 to 10,000 Da), and low molecular weights (below 5,000 Da) were fractionated using an ultrafiltration membrane system. The below 5,000 Da hydrolysate exhibited the highest ACE inhibitory activity. These results indicate that the pepsinolytic hydrolysates of elk velvet antler could be a good source of peptides with ACE inhibitory activity.
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KEYWORD
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angiotensin I-converting enzyme (ACE), antler, proteolysis, hydrolysate, peptide
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