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KMID : 1160620050100030244
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Preventive Nutrition and Food Science
2005 Volume.10 No. 3 p.244 ~ p.250
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Tyrosinase Inhibitory and Antioxidant Activities of Korean Mistletoe (Viscum album var. coloratum) Extract and Its Fractions
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Lyu Su-Yun
Moon You-Sun
Park Won-Bong
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Abstract
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The copper-containing enzyme, tyrosinase, catalyzes the oxidation of tyrosine into dihydroxy phenylalanine (DOPA) and subsequently DOPAquinone. It is responsible, not only for the pigment melanin biosynthesis in human skin, but also for browning in foods. In the present study, tyrosinase inhibitory and antioxidant activities of Korean mistletoe extract and its fractions were investigated. As a result, both water and methanol (MeOH) extracts inhibited the tyrosinase activity. Among the fractions, the fraction eluted with 95% MeOH significantly inhibited the tyrosinase activity. The fraction was further purified, and the purified fraction C strongly inhibited the enzyme activity up to 92%. In addition, water and methanol extracts exerted radical scavenging effects. The fractions eluted with 70% MeOH and 95% MeOH showed high radical scavenging activities. In conclusion, these results suggest that Korean mistletoe extract and its fractions might be useful for the treatment of various dermatological disorders such as epidermal hyperpigmentation and for improving food quality.
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KEYWORD
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mistletoe, tyrosinase, melanin, inhibition, antioxidant
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