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KMID : 1160620050100030257
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Preventive Nutrition and Food Science
2005 Volume.10 No. 3 p.257 ~ p.261
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Cytotoxic Effects of Furanosesterterpenes, Cyclitol Derivatives, and Bromotyrosine Derivative Isolated from Marine Sponges
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Sohn Jae-Hak
Oh Hyun-Cheol
Jung Jee-H.
Bae Song-Ja
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Abstract
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Marine sponges are known to produce a number of cytotoxic secondary metabolites. In the course of searching for cytotoxic metabolites from marine organisms, we have evaluated cytotoxic activities of six marine secondary metabolites isolated from various sponges. The cytotoxic compounds 1~6 were isolated by the application of various chromatographic methods, including column chromatography and HPLC. The molecular structures were mostly determined using mass spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy. Furanosestererpenes (compounds 1~3) from Psammocinia sp., cyclitol derivatives (compounds 4 and 5) from Sarcotragus sp., and bromotyrosine-type compound (6) from an association of two sponges Jaspis wondoensis and Poecillastra wondoensis were evaluated for their cytotoxic activity against three cancer cell lines; Hep G2, HeLa, and MCF-7. All tested compounds exhibited cyctoxicity at concentrations ranging from 5 ㎍/mL to 25 ㎍/mL. Particularly, among the tested compounds, compound 6 showed the highest potency displaying at least 80% of cytotoxicity at 5 ㎍/mL level against all three cancer cell lines.
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KEYWORD
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sponges, cytotoxicity, furanosesterterpenes, cyclitol derivatives, bromotyrosine, human cancer cell lines
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