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KMID : 1160620050100030267
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Preventive Nutrition and Food Science
2005 Volume.10 No. 3 p.267 ~ p.271
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Anthraquinones with Immunostimulating Activity from Cassia tora L.
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Chung Ha-Sook
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Abstract
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Many of plants had been reported having immunostimulating activity. This study reports the immunostimulating activity of Cassia tora L. (Leguminosae) seed, by means of solvent extraction method. Ethanol extract and solvent fractions, n-hexane, chloroform, ethylacetate, n-butanol and aqueous layer of Cassia tora L. seed were tested for immunostimulating activity in vitro. The ethylacetate-soluble fraction caused significant inhibition on the production of nitric oxide by murine macrophages (RAW 264.7), and mouse splenocytes were also stimulated at the concentration of 10 pgfmL. Three anthraquinones, chrysophanol (1), isochrysophanol (2) and aloe-emodin (3) with immunostimulating activity were isolated from the ethylacetate-soluble fraction of Cassia tora L. seed through activity-monitored fractionation and isolation method. These results permit Cassia tora L. to be useful as one the of natural immunostimulating crops.
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KEYWORD
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Cassia tora L., Leguminosae, anthraquinone, nitric oxide, macrophage, splenocyte, phytochemicals, in vitro
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