|
KMID : 1160620050100040344
|
|
Preventive Nutrition and Food Science
2005 Volume.10 No. 4 p.344 ~ p.348
|
|
|
Effects of Fucoidan on NO Production and Phagocytosis of Macrophages and the Proliferation of Neuron Cells
|
|
Hang Do
Choi Hye-Sook
Kang Se-Chan
Kim Kyung-Ran
Sohn Eun-Soo
Kim Mi-Hyun
Pyo Suhk-Neung
Son Eun-Wha
|
|
|
Abstract
|
|
|
|
Fucoidans, high-molecular-weight sulfated polysaccharides extracted from brown seaweeds, have various biological activities. Here we examined whether fucoidan could increase the immunomodulation and proliferation capacity of cells in vitro. When peritoneal macrophages were treated with various concentrations of fucoidan (1~100 μg/mL) for 24 hours, NO production was significantly increased. In addition, exposure of macrophages to 10 μg/mL of fucoidan induced a phagocytic activity. Treatment of neuroblastoma cells (SK-N-SH) with fucoidan enhanced cell proliferation and NO production in a concentration-dependent manner. These results indicate that fucoidan has both immunomodulatory and cell proliferative properties, and may thus be a a candidate for development as an immunomodulating agent.
|
|
|
KEYWORD
|
|
|
fucoidan, nitric oxide, phagocytosis, immunomodulation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|