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KMID : 1160620050100040353
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Preventive Nutrition and Food Science
2005 Volume.10 No. 4 p.353 ~ p.356
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The Effects of Boron on the Proliferation of Osteoblastic and Neuroblastoma Cells
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Choi Hye-Sook
Hang Do
Choi Mi-Kyeong
Lee Sung-Ryul
Pyo Suhk-Neung
Son Eun-Wha
Kim Mi-Hyun
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Abstract
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It has been recently reported that boron affects bone metabolism in humans and animals. In this study we examined whether boron affects the proliferation on various cell types, MG-63, HOS, Raw 264.7 and SK-N-SH. When treated with different concentrations of boron (1, 10, 100 M) for 24 and 48 hr, the proliferation of MG-63 cells was enhanced at 10 M (p<0.05), for 24 hr. In HOS cells, boron had no effect on cell proliferation at 24 or 48 hr. In addition, treatment of pre-osteoclastic cells (Raw 264.7) with 1, 10, 100 M boron resulted in no effect on cell proliferation. Proliferation of neuronal cells (SK-N-SH) was enhanced by boron in a concentration dependent manner at low concentrations (0.1, 0.5, 1 M). Besides proliferation activity, boron has an effect on the enhancement of NO production in SK-N-SH cells in a concentration-dependent manner. These studies showed that boron enhances proliferation of osteoblastic cells (especially MG-63), depending upon the concentration of boron. These results also provide further evidence of the positive effects of boron in neuronal disease.
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KEYWORD
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boron, proliferation, MG-63, HOS, Raw 264.7, SK-N-SH
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