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KMID : 1160620060110010001
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Preventive Nutrition and Food Science
2006 Volume.11 No. 1 p.1 ~ p.5
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Conjugated Linoleic Acid Reduction of Vascular Endothelial Growth Factor Expression in Murine Mammary Tumor Cells through Alteration of Prostaglandin E2
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Kim Jung-Hyun
Hubbard Neil E.
Lim Debora
Erickson Kent L.
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Abstract
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Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid that have been used to reduce the incidence, growth and metastasis of breast, colon, prostate and gastric cancer in animals. CLA could reduce tumor growth by altering angiogenesis; a process requiring associated angiogenic factors such as vascular endothelial growth factor (VEGF). In this study, we determined whether CLA could modulate the expression of VEGF in murine mammary tumor cells and adipocytes. The c9, t11-CLA isomer reduced VEGF transcripts and protein when mammary tumor cells were stimulated with PMA. That isomer also reduced VEGF expression in un stimulated mouse 3T3-L1 adipocytes. Since VEGF can be regulated by cyclooxygenase-2 (COX-2), we determined whether CLA could alter COX-2 enzyme expression and PGE2 production. The c9, t11-CLA isomer reduced not only COX-2 enzyme expression but also PGE2 production. Thus, c9, t11-CLA could modulate neovascularization by alteration of VEGF expression from mammary tumor cells and adipocytes by reducing COX-2 metabolites.
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KEYWORD
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conjugated linoleic acid, vascular endothelial growth factor, cyclooxygenase, prostaglandin E2
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