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KMID : 1160620060110040261
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Preventive Nutrition and Food Science
2006 Volume.11 No. 4 p.261 ~ p.267
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Physiological Activities of Different Molecular Weight Fractions of Crude Polysaccharides from Dodok (Codonopsis lanceolata)
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Kim Dong-Soo
Kim Byoung-Mok
Lee Myung-Ki
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Abstract
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This study investigated the physiological activities of different molecular weight (MW) fractions of crude polysaccharide from D?d?k (Codonopsis lanceolata). The crude polysaccharide cut off for each fraction was: ＜1,000 MW (Fr Ⅰ), 1,000 MW＜fraction＜3,000 MW (Fr Ⅱ), 3,000 MW＜fraction＜10,000 MW (Fr Ⅲ), 10,000 MW＜fraction＜100,000 MW (Fr Ⅳ), 100,000 MW＜fraction (Fr Ⅴ) with membrane. Fr Ⅰ exhibited the highest yield of all the fractions. Fr Ⅰ also had the highest total sugar contents, total protein contents, total phenolic compounds content, as well as the greatest growth inhibitory activity against SNU-1 and Hela cells, ACE inhibitory activity, and DPPH radical scavenging effect. Fr Ⅱ exhibited lower physiological activity than Fr Ⅰ, and showed higher activity than those of fraction of above 3,000 MW, but there was no significant ACE inhibitory activity. The Fr Ⅲ exhibited the lowest yield, total sugar contents, total protein contents, and total phenolic contents; as well as the least growth inhibitory activity against SNU-1, Hela, ACE inhibitory activity, DPPH radical scavenging effect.
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KEYWORD
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physiological activities, polysaccharide, Codonopsis lanceolata
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