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KMID : 1160620070120010001
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Preventive Nutrition and Food Science
2007 Volume.12 No. 1 p.1 ~ p.6
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Effects of Colostrum Basic Protein from Colostrum Whey Protein: Increases in Osteoblast Proliferation and Bone Metabolism
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Lee Jeong-Rai
Kim Hyun-Mi
Choi Hee-Sun
Hong Jeong-Hwa
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Abstract
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Colostrum basic proteins (CBP) (MW 1$sim$30 kDa) were isolated from bovine colostrum using a series of ultrafiltration processes and their effects on osteoblast cell proliferation and bone metabolism were investigated in cell line and animal models. Treatments with CBP (1, 10, 100 $mu$g/mL) dose-dependently increased cell proliferation of osteoblastic MC3T3 cells. Alkaline phosphatase activity, a marker of osteoblastic phenotype, in the cells was also increased after treatments with CBP in a dose-dependent manner. Significant increases in bone density were observed in femur of ovariectomized rats which were fed a diet with 1% and 10% CBP, compared to rats fed a normal diet. These results suggest that CBP may increase bone mass and density and be useful for the prevention of bone-related diseases.
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KEYWORD
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colostrum basic protein, osteoblast, bone density, alkaline phosphatase activity
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