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KMID : 1160620070120010029
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Preventive Nutrition and Food Science
2007 Volume.12 No. 1 p.29 ~ p.34
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Production of a High Value-Added Soybean Containing Bioactive Mevinolins and Isoflavones
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Pyo Young-Hee
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Abstract
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The production of mevinolin, a potent hypocholesterolemic drug, and the bioconversion of isoflavones were investigated in soybeans fermented with Monascus pilosus KFRI-1140. The highest yields of 2.94 mg mevinolins and 1.13 mg isoflavone aglycones per g dry weight of soybean were obtained after 20 days of fermentation. Mevinolin was present in the fermentation substrate predominantly in the hydroxycarboxylate form (open lactone, 94.8$sim$96.7%), which is currently being used as an hypocholesterolemic agent. The significant (p<0.01) bioconversion (96.6%) of the glucoside isoflavones (daidzin, glycitin, genistin) present in the soybean to the bioactive aglycones (daidzein, glycitein, genistein), with a 15.8-fold increase of aglycones was observed. The results suggest that Monascus-fermented soybean has potential as a novel medicinal food or multifunctional food supplement.
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KEYWORD
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hypocholesterolemic agent, isoflavones, medicinal food, mevinolin, Monascus-fermented soybean
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