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KMID : 1160620080130040253
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Preventive Nutrition and Food Science
2008 Volume.13 No. 4 p.253 ~ p.258
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Anti-inflammatory Activity of an Ethanol Extract of Caesalpinia sappan L. in LPS-induced RAW 264.7 Cells
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Jeong Il-Yun
Jin Chang-Hyun
Park Yong-Dae
Lee Hyo-Jung
Choi Dae-Seong
Byun Myung-Woo
Kim Yeung-Ji
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Abstract
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The anti-inflammatory activities of an ethanol extract of Caesalpinia sappan L. (CS) were investigated in LPS-induced RAW 264.7 cells. Result indicated that CS inhibited the LPS-induced NO production in a dose-dependent manner with an IC50 of 10.9 μg/mL. In addition, CS attenuated the iNOS mRNA and protein expression by inhibiting NF-κB activation. CS also suppressed the productions of IL-6 and MCP-1 in a dose-dependent manner, with IC50 values of 15.9 μg/mL and 5.47 μg/mL, respectively. In addition to the anti-inflammatory activities, CS decreased intracellular ROS formation in the same cells. In conclusion, CS inhibited the production of NO, IL-6 and MCP-1 via a suppression of the NF-κB activation and intracellular ROS generation.
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KEYWORD
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Caesalpinia sappan, nitric oxide, iNOS (inducible nitric oxide synthase), NF-κB (nuclear factor kappa B), IL-6 (interleukin-6)
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