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KMID : 1160620080130040362
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Preventive Nutrition and Food Science
2008 Volume.13 No. 4 p.362 ~ p.365
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Inhibition of Inducible Nitric Oxide Synthase by Agaricus bisporus Extract in RAW 264.7 Macrophages
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Ahn Ji-Yun
Lee Hyun-Jung
Moon Mi-Kyung
Kim Su-Na
Ha Tae-Youl
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Abstract
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Agaricus bisporus, also known as white button mushroom, is one of the most popular mushrooms consumed in Korea. This mushroom contains high concentrations of flavanoids and exhibits antioxidant activity. In this study, we examined the effects of Agaricus bisporus ethanol extract (ABE) on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells. Nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) protein levels were assessed in cells treated with 100 μM LPS in the presence or absence of ABE. 0.5 mg/mL of ABE suppressed NO production significantly. Moreover, ABE inhibited levels of iNOS protein. Taken together, these results suggest that ABE exerts anti-inflammatory activity in LPS-induced inflammation in RAW 264.7 cells.
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KEYWORD
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Agaricus bisporus, anti-inflammatory effect, nitric oxide, inducible nitric oxide synthase
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