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KMID : 1160620090140010014
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Preventive Nutrition and Food Science
2009 Volume.14 No. 1 p.14 ~ p.20
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Effect of N-Acetylcysteine on the Matrix Metalloproteinases and Their Inhibitors in Carbon Tetrachloride-Induced Hepatotoxicity
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Kamalakkannan N.
Al-Numair Khalid S.
Al-Assaf Abdullah H.
Al-Shatwi Ali A.
Menon V. P.
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Abstract
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Matrix metalloproteinases (MMPs) are a group of zinc proteases that serve the function of breaking down extracellular matrix (ECM). The present study evaluated the role of N-acetylcysteine (NAC) on the increased deposition of ECM in hepatic and glomerular fibrosis caused by carbon tetrachloride (CCl4). The activity of MMPs increased and the levels of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) decreased in the liver and kidney of CCl4-treated rats. Rats treated with CCl4 and NAC showed increased activities of MMPs and decreased levels of TIMP-1 and TIMP-2 in the liver and kidney. Treatment with NAC resulted in the effective degradation of ECM due to an increase in the activities of MMPs and a decrease in the levels of TIMPs.
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KEYWORD
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matrix metalloproteinases, carbon tetrachloride, N-acetylcysteine, Wistar rats, liver, kidney
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