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KMID : 1160620090140010037
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Preventive Nutrition and Food Science
2009 Volume.14 No. 1 p.37 ~ p.42
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Protective Activity of Seolitae Chungkukjang Added with Green Tea against Cellular Oxidative Stress induced by AAPH
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Park Hyun-Young
Lee Hee-Seob
Cho Eun-Ju
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Abstract
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The protective activity of seolitae chungkukjang added with green tea against oxidative stress was investigated under the cellular systems using LLC-PK1 cells. The treatment of 2,2'-azobis(2-aminopropane) dihydrochloride (AAPH) showed increase in lipid peroxidation, and decrease in endogenous antioxidant enzymes activity and cell viability. However, the methanol extract of seolitae chungkukjang inhibited lipid peroxidation by 58.3%, and increased cell viability up to more than 60%. In addition, it enhanced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Seolitae chungkukjang improved oxidative stress-induced cellular injury through the radical scavenging activities. In particular, the addition of green tea in seolitae chungkukjang showed stronger effect against oxidative stress induced by AAPH. The more addition of green tea resulted in the greater antioxidative effect through elevation in activities of SOD and GSH-Px, and inhibition of lipid peroxidation, eventually leading to increase in cell viability. Theses results suggested that seolitae chungkukjang added with green tea have protective effects from cellular oxidative damage and could be considered as an application for the development of chungkukjang with functionality.
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KEYWORD
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seolitae, chungkukjang, green tea, 2,2'-azobis (2-aminopropane) dihydrochloride, LLC-PK1
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