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KMID : 1160620100150010001
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Preventive Nutrition and Food Science
2010 Volume.15 No. 1 p.1 ~ p.6
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Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet
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Endo Michiko
Kasaoka Seiichi
Takizawa Miki
Goto Kiyoko
Nakajima Shigeru
Moon Soo-Kyung
Kim In-Soo
Jeong Bo-Young
Nakamura Soichiro
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Abstract
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The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-76TM) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.
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KEYWORD
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wistar rat, histidine-enriched diet, adipose tissue mass, fat accumulation, 3-methylhistidine, carnosine
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