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KMID : 1160620130180030157
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Preventive Nutrition and Food Science
2013 Volume.18 No. 3 p.157 ~ p.162
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Effects of the Cynanchum wilfordii Ethanol Extract on the Serum Lipid Profile in Hypercholesterolemic Rats
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Lee Hye-Sung
Choi Jun-Hyeok
Kim Young-Eon
Kim In-Ho
Kim Byoung-Mok
Lee Chang-Ho
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Abstract
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The purpose of this study was to investigate the effects of the ethanol extract of Cynanchum wilfordii (ECW) on the blood lipid profile of hypercholesterolemic rats. Thirty 7-week-old male Sprague-Dawley rats were allowed free ac-cess to either a normal diet (AIN-93 diet), or 1% high-cholesterol diet with or without 0.5% or 1% ECW for 5 weeks. After sacrifice, the rat serum lipid profile was analyzed. The diets containing ECW decreased body weight gains com-pared to the normal diet. Serum HDL-cholesterol levels of ECW-fed groups were significantly increased in the hyper-cholesterolemic groups and normal groups (P<0.05). When 1% ECW was fed to the normal group, total cholesterol level was increased. Moreover, treatment of ECW in hypercholesterolemic groups yielded a dose-dependent and highly sig-nificant decrease in the atherogenic index as compared to the control. These results suggest that intake of Cynanchum wil-fordii may help reduce the risks of hypercholesterolemia by increasing blood HDL-cholesterol and lowering the athero-genic index.
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KEYWORD
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atherogenic index, Cynanchum wilfordii, HDL-cholesterol, hypercholesterolemia, LDL-cholesterol
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