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KMID : 1160620130180030181
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Preventive Nutrition and Food Science
2013 Volume.18 No. 3 p.181 ~ p.187
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Anticoagulant and Antiplatelet Activities of Artemisia princeps Pampanini and Its Bioactive Components
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Ryu Ri
Jung Un-Ju
Kim Hye-Jin
Lee Won-Hwa
Bae Jong-Sup
Park Yong-Bok
Choi Myung-Sook
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Abstract
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Artemisia princeps Pampanini (AP) has been used as a traditional medicine in Korea, China and Japan and re-ported to exhibit various beneficial biological effects including anti-inflammatory, antioxidant, anti-atherogenic and lipid lowering activities; however, its antiplatelet and anticoagulant properties have not been studied. In the present study, we evaluated the effects of an ethanol extract of Artemisia princeps Pampanini (EAP) and its major flavonoids, eupatilin and jaceosidin, on platelet aggregation and coagulation. To determine the antiplatelet activity, arachidonic acid (AA)-, colla-gen- and ADP (adenosine diphosphate)-induced platelet aggregation were examined along with serotonin and thrombox-ane A2 (TXA2) generation in vitro. The anticoagulant activity was determined by monitoring the activated partial throm-boplastin time (aPTT) and prothrombin time (PT) in vitro. The data showed that EAP and its major flavonoids, eupatilin and jaceosidin, significantly reduced AA-induced platelet aggregation and the generation of serotonin and TXA2, although no significant change in platelet aggregation induced by collagen and ADP was observed. Moreover, EAP significantly prolonged the PT and aPTT. The PT and/or aPTT were significantly increased in the presence of eupatilin and jaceosidin. Thus, these results suggest that EAP may have the potential to prevent or improve thrombosis by inhibiting platelet acti-vation and blood coagulation.
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KEYWORD
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Artemisia princeps Pampanini, eupatilin, jaceosidin, anticoagulation, antiplatelet
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