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KMID : 1160620140190020075
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Preventive Nutrition and Food Science
2014 Volume.19 No. 2 p.75 ~ p.81
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Antioxidant Effects of Cranberry Powder in Lipopolysaccharide Treated Hypercholesterolemic Rats
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Kim Mi-Joung
Kim Jung-Hee
Kwak Ho-Kyung
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Abstract
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This study was conducted to investigate the effects of cranberry power on antioxidant defense system in rats fed an atherogenic diet and injected with lipopolysaccharide (LPS). Sprague-Dawley rats were divided into the following 5 groups: normal diet+saline (NS), atherogenic diet+saline (AS), atherogenic diet+LPS (AL), atherogenic diet with 5% cranberry powder+LPS (AL-C5), and atherogenic diet with 10% cranberry powder+LPS (AL-C10). Total antioxidant sta-tus measured by ferric reducing ability of plasma (FRAP) was significantly reduced by LPS injection (24%) and was re-stored by the cranberry powder treatment (P<0.05). In addition, the mean level of plasma total phenolics was sig-nificantly decreased by LPS injection (P<0.05) and tended to be increased when cranberry powder was incorporated in to the diet. Activity of serum superoxide dismutase (SOD) tended to be lowered by LPS injection and declined further in cranberry powder fortified groups. Overall results indicate that dietary cranberry powder may provide appropriate anti-oxidants to counter the diminished antioxidant status induced by exposing hypercholesterolemic rats to LPS.
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KEYWORD
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cranberry powder, atherogenic diet, rat, lipopolysaccharide, oxidative stress
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