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KMID : 1160620140190030129
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Preventive Nutrition and Food Science
2014 Volume.19 No. 3 p.129 ~ p.135
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Phloroglucinol Attenuates Free Radical-induced Oxidative Stress
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So Mi-Jung
Cho Eun-Ju
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Abstract
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ABSTRACT: The protective role of phloroglucinol against oxidative stress and stress-induced premature senescence (SIPS) was investigated in vitro and in cell culture. Phloroglucinol had strong and concentration-dependent radical scav-enging effects against nitric oxide (NO), superoxide anions (O2?), and hydroxyl radicals. In this study, free radical gen-erators were used to induce oxidative stress in LLC-PK1 renal epithelial cells. Treatment with phloroglucinol attenuated the oxidative stress induced by peroxyl radicals, NO, O2?, and peroxynitrite. Phloroglucinol also increased cell viability and decreased lipid peroxidation in a concentration-dependent manner. WI-38 human diploid fibroblast cells were used to investigate the protective effect of phloroglucinol against hydrogen peroxide (H2O2)-induced SIPS. Phloroglucinol treatment attenuated H2O2-induced SIPS by increasing cell viability and inhibited lipid peroxidation, suggesting that treatment with phloroglucinol should delay the aging process. The present study supports the promising role of phlor-oglucinol as an antioxidative agent against free radical-induced oxidative stress and SIPS.
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KEYWORD
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phloroglucinol, oxidative stress, nitric oxide, LLC-PK1 cells, WI-38 cells
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