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KMID : 1160620140190030156
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Preventive Nutrition and Food Science
2014 Volume.19 No. 3 p.156 ~ p.163
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Effects of High-Protein Diet and/or Resveratrol Supplementation on the Immune Response of Irradiated Rats
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Kim Kyoung-Ok
Park Hyun-Jin
Kim Hyun-Sook
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Abstract
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We investigated the effects of a high-protein diet and resveratrol supplementation on immune cells changes induced by abdominal irradiation in rats. Female Wistar rats were divided into 5 groups: 1) control diet, 2) control diet with irradiation 3) 30% high-protein diet with irradiation, 4) normal diet with resveratrol supplementation and irradi-ation, and 5) 30% high-protein diet with resveratrol supplementation and irradiation. We measured blood protein and al-bumin concentrations, lipid profiles, white blood cell (WBC) counts, proinflammatory cytokine production, and spleno-cyte proliferation in rats that had been treated with a 17.5 Gy dose of radiation 30 days prior. A high-protein diet affected plasma total cholesterol and very low density lipoprotein-cholesterol levels, which were increased by the radiation treatment. In addition, the lymphocyte percentage and immunoglobulin M (IgM) concentration were increased, and the neutrophil percentage was decreased in rats fed a high-protein diet. Resveratrol supplementation decreased the trigly-ceride (TG) level, but increased the IgM concentration and splenocyte proliferation. Proinflammatory cytokine production was lower in rats fed a high-protein diet supplemented with resveratrol than in rats fed a control diet. The results of the present study indicate that high-protein diets, with or without resveratrol supplementation, might assist with recovery from radiation-induced inflammation by modulating immune cell percentages and cytokine production.
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KEYWORD
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radiation treatment, high-protein diet, resveratrol, immune function, inflammation
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