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KMID : 1160620140190030187
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Preventive Nutrition and Food Science
2014 Volume.19 No. 3 p.187 ~ p.193
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Anti-adipogenic and Pro-osteoblastogenic Activities of Spergularia marina Extract
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Karadeniz Fatih
Kim Jung-Ae
Ahn Byul-Nim
Kim Mi-Hyang
Kong Chang-suk
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Abstract
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For decades, Spergularia marina, a local food that is popular in South Korea, has been regarded as a nutritious source of amino acids, vitamins, and minerals. While several halophytes are reported to possess distinct bioactivities, S. marina has yet to be promoted as a natural source of bioactives. In this study, the effects of S. marina on the adipogenic differentiation of 3T3-L1 fibroblasts and the osteoblastic differentiation of MC3T3-E1 pre-osteoblasts and C2C12 myo-blast cells were evaluated. The anti-adipogenic effect of S. marina was assessed by measuring lipid accumulation and adi-pogenic differentiation marker expression. S. marina treatment significantly reduced lipid accumulation and notably de-creased the gene levels of peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α, and sterol regulatory element binding protein 1c. In addition, S. marina enhanced osteoblast differentiation, as indicated by in-creased alkaline phosphatase activity and increased levels of osteoblastogenesis indicators, namely bone morphogenetic protein-2, osteocalcin, and type I collagen. In conclusion, S. marina could be a source of functional food ingredients that improve osteoporosis and obesity. Further studies, including activity-based fractionation, will elucidate the mechanism of action and active ingredients of S. marina, which would provide researchers with a better understanding of the nu-traceutical and therapeutic applications of S. marina.
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KEYWORD
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osteoporosis, adipogenesis, osteoblastogenesis, halophyte, Spergularia marina
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