KMID : 1160620140190040343
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Preventive Nutrition and Food Science 2014 Volume.19 No. 4 p.343 ~ p.347
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Vaccinium uliginosum L. Improves Amyloid ¥â Protein-Induced Learning and Memory Impairment in Alzheimer's Disease in Mice
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Choi Yoon-Hee
Kwon Hyuck-Se Shin Se-Gye Chung Cha-Kwon
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Abstract
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The present study investigated the effects of Vaccinium uliginosum L. (bilberry) on the learning and memory impairments induced by amyloid-¥â protein (A¥âP) 1-42. ICR Swiss mice were divided into 4 groups: the control (A¥â40-1A), control with 5% bilberry group (A¥â40-1B), amyloid ¥â protein 1-42 treated group (A¥â1-42A), and A¥â1-42 with 5% bilberry group (A¥â1-42B). The control was treated with amyloid ¥â-protein 40-1 for placebo effect, and Alzheimer¡¯s disease (AD) group was treated with amyloid ¥â-protein 1-42. Amyloid ¥â-protein 1-42 was intracerebro-ventricular (ICV) micro injected into the hippocampus in 35% acetonitrile and 0.1% trifluoroacetic acid. Although bil-berry added groups tended to decrease the finding time of hidden platform, no statistical significance was found. On the other hand, escape latencies of A¥âP injected mice were extended compared to that of A¥â40-1. In the Probe test, bilberry added A¥â1-42B group showed a significant (P£¼0.05) increase of probe crossing frequency compared to A¥â1-42A. Administration of amyloid protein (A¥â1-42) decreased working memory compared to A¥â40-1 control group. In passive avoidance test, bilberry significantly (P£¼0.05) increased the time of staying in the lighted area compared to AD control. The results suggest that bilberry may help to improve memory and learning capability in chemically induced Alzheimer¡¯s disease in experimental animal models.
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KEYWORD
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Vaccinium uliginosum L., Alzheimer¡¯s disease, hidden platform, passive avoidance, hippocampus
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