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KMID : 1160620150200040230
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Preventive Nutrition and Food Science
2015 Volume.20 No. 4 p.230 ~ p.237
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Microalgal Oil Supplementation Has an Anti-Obesity Effect in C57BL/6J Mice Fed a High Fat Diet
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Yook Jin-Seon
Kim Kyung-Ah
Park Jeong-Eun
Lee Seon-Hwa
Cha Youn-Soo
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Abstract
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This study investigated the impact of microalgal oil (MO) on body weight management in C57BL/6J mice. Obesity was induced for 8 weeks and animals were orally supplemented with the following for 8 additional weeks: beef tallow (BT), corn oil, fish oil (FO), microalgal oil (MO), or none, as a high fat diet control group (HD). A normal control group was fed with a normal diet. After completing the experiment, the FO and MO groups showed significant decreases in body weight gain, epididymal fat pad weights, serum triglycerides, and total cholesterol levels compared to the HD and BT groups. A lower mRNA expression level of lipid anabolic gene and higher levels of lipid catabolic genes were observed in both FO and MO groups. Serum insulin and leptin concentrations were lower in the MO group. These results indicated that microalgal oil has an anti-obesity effect that can combat high fat diet-induced obesity in mice.
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KEYWORD
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microalgae, omega-3, polyunsaturated fatty acids, lipid profile, obesity
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