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KMID : 1160620160210010068
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Preventive Nutrition and Food Science
2016 Volume.21 No. 1 p.68 ~ p.72
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Physiological Activities of Thiacremonone Produced in High Temperature and High Pressure Treated Garlic
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Woo Koan-Sik
Hwang In-Guk
Kim Hyun-Young
Lee Sang-Hoon
Jeong Heon-Sang
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Abstract
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To examine the possibility of using thiacremonone isolated from high-temperature-high-pressure treated garlic, this study investigated the physiological activities properties. The IC50 values of hydroxyl, superoxide, hydrogen peroxide, and nitric oxide radical scavenging activities of thiacremonone were 92.50, 65.05, 12.60, and 81.53 ?g/mL, re-spectively. On the other hand, the activities of vitamin C were 104.93, 99.43, 42.42, and 122.64 ?g/mL, and the activities of butylated hydroxyanisole were 37.22, 68.45, 22.47, and 40.54 ?g/mL, respectively. The IC50 value of ACE inhibition activities of thiacremonone and captoprill were 0.265 and 0.036 ?g/mL, respectively. The IC50 value of xanthine oxidase inhibition activities of thiacremonone and allopurinol were 39.430 and 9.346 ?g/mL, respectively. The IC50 value of ty-rosinase inhibition activities of thiacremonone and kojic acid were 101.931 and 65.648 ?g/mL, respectively.
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KEYWORD
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thiacremonone, 2,4-dihydroxy-2,5-dimethyl-thiophene-3-one, garlic (Allium sativum L.), radical scavenging activity
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