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KMID : 1160620160210030181
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Preventive Nutrition and Food Science
2016 Volume.21 No. 3 p.181 ~ p.186
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Gynura procumbens Extract Alleviates Postprandial Hyperglycemia in Diabetic Mice
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Choi Sung-In
Park Mi-Hwa
Han Ji-Sook
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Abstract
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This study was designed to investigate the inhibitory effect of Gynura procumbens extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. G. procumbens extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC50) of G. procumbens extract against α-glucosidase and α-amylase was 0.092±0.018 and 0.084±0.027 mg/mL, respectively, suggesting that the α-amylase inhibition activity of the G. procumbens extract was more effective than that of the positive control, acarbose (IC50=0.164 mg/mL). The increase in postprandial blood glucose levels was more significantly alleviated in the G. procumbens extract group than in the control group of STZ-induced diabetic mice. Moreover, the area under the curve significantly decreased with G. procumbens extract administration in STZ-induced diabetic mice. These results suggest that G. procumbens extract may help alleviate postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.
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KEYWORD
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Gynura procumbens extract, α-glucosidase, α-amylase, postprandial hyperglycemia
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