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KMID : 1160620190240040492
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Preventive Nutrition and Food Science
2019 Volume.24 No. 4 p.492 ~ p.497
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Standardized Seed Extract of Quisqualis indica (HU-033) Attenuates Testosterone Propionate-Induced Benign Prostatic Hyperplasia via α1-Adrenergic Receptors and Androgen/Estrogen Signaling
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Baek Jong-Min
Kim Hyun-Jun
Nam Min-Woo
Park Hyun-Jin
Yeon Sung-Hum
Oh Myeong-Hwan
Yoon Ji-Soo
Kwon Hyo-Jung
Lee Kyu-Pil
Lim Jong-Hwan
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Abstract
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Benign prostatic hyperplasia (BPH) is an age-related disease characterized by prostatic enlargement and is the most common urologic symptoms in elderly men 60 years of age and older. Previously, we documented that 70% ethanol (EtOH) seed extract of Quisqualis indica (QI) attenuates pathological condition of testosterone propionate (TP)-induced BPH rat model via modulation of proliferation and apoptosis of prostate cells. Based on this potential of QI, we produced standardized seed extract of QI (HU-033) in order to prove further mechanisms. In this study, we aimed to suggest further mechanisms underlying the relationship between BPH and HU-033. Through not only cellular and nuclear receptor functional assays, but TP-mediated BPH rat model treated with HU-033, we demonstrated that HU-033 exerted antagonist effect on α1A- and α1D-adrenergic receptors in vitro and inhibitory effect on protein expression of androgen receptor and estrogen receptor alpha in vivo. Taken together, these results suggest that HU-033 is a novel candidate for the management of BPH.
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KEYWORD
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HU-033, benign prostate hyperplasia, α1-adrenergic receptor, estrogen receptor α, androgen receptor
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