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KMID : 1160620200250010093
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Preventive Nutrition and Food Science
2020 Volume.25 No. 1 p.93 ~ p.97
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Bioactive Peptide Tempe Made from Mucuna pruriens (L) DC as an Inhibitor of Angiotensin-I-Converting Enzyme (ACE) in a Digestion Simulation
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Rizkaprilisa Windy
Marsono Yustinus
Indrati Retno
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Abstract
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Mucuna pruriens (L) DC tempe is a food that functions as an inhibitor of the angiotensin-I-converting enzyme (ACE). The purpose of this research was to study the activity of M. pruriens tempe peptides during the digestive process in vitro with pepsin-pancreatin, and absorption of peptides in the small intestine using the inverted intestinal sac method. Our results show that M. pruriens had the highest ACE-inhibiting activity after digestion in vitro after fermentation for 72 h (F72). F72 peptide absorption (%) and ACE-inhibitory activity of the absorbed peptides did not significantly differ between the different segments of the small intestine (duodenum, jejunum, and ileum). These results demonstrate that F72 tempe maintains ACE-inhibitory activity in each segment of the small intestine after both digestion and absorption.
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KEYWORD
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ACE inhibitors, Mucuna pruriens (L) DC, peptide absorption, simulated digestion, tempe
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