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KMID : 1160620210260030307
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Preventive Nutrition and Food Science
2021 Volume.26 No. 3 p.307 ~ p.314
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Effects of Sargassum horneri and Ulva australis Extracts on Body Weight and Serum Glucose Levels of Sprague-Dawley Rats
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Lee Young-Hyeon
Yeo Min-Ho
Yoon Seon-A
Hyun Ho-Bong
Ham Young-Min
Jung Yong-Hwan
Chang Kyung-Soo
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Abstract
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This study investigated the safety and functionality of a functional additive for humans and animals from Sargassum horneri (SH) and Ulva australis (UA) waste for recycling marine refuse generated in large quantities in Jeju. Sprague-Dawley rats were orally administered functional additives at 2,000 mg/kg to assess 14-day repeated dose toxicity of the two extracts. For female rats, weight gain after administration of SH was 66.2±18.8% vs. controls. Male rats administered UA showed weight gain of 92.3±8.0% vs. controls. SH and UA significantly decreased serum glucose levels in male rats compared with controls (79.8±11.10% and 76.1±9.67%, respectively). Similarly, significant decrease in serum glucose levels were shown for female rats after administration of SH and UA (79.2±1.58% and 82.8±3.21%, respectively). Furthermore, rats showed significant differences vs. controls in several serological parameters after receiving extracts, however results remained within the normal range. Thus, the SH and UA extracts were considered safe substances that may be used as functional additives to help reduce body weight and serum glucose.
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KEYWORD
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functional natural additive, Sargassum horneri, safety evaluation, serum glucose, Ulva australis
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