KMID : 1160620220270040423
|
|
Preventive Nutrition and Food Science 2022 Volume.27 No. 4 p.423 ~ p.435
|
|
Fish Collagen Peptide (Naticol¨Þ) Protects the Skin from Dryness, Wrinkle Formation, and Melanogenesis Both In Vitro and In Vivo
|
|
Lee Min-Hee
Kim Da-Kyung Park Seong-Hoo Jung Jae-Eun Cho Won-hee Yu A-Ram Lee Jeong-Min
|
|
Abstract
|
|
|
Consistent ultraviolet B (UVB) radiation exposure results in dry skin, wrinkles, and melanogenesis. In this study, we investigated whether fish collagen peptide (Naticol¨Þ) could inhibit photoaging and oxidative stress in skin exposed to UVB using cell and animal models. We measured the skin hydration, histological observations, antioxidant activities, moisturizing-related factors, collagen synthesis-related factors, and melanogenesis-related factors in skin cells and animal skin using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blot assay. Naticol¨Þ collagen improved skin moisturization via hyaluronic acid and ceramide synthesis-related factors in HaCaT cells and SHK-I hairless mice that were exposed to UVB. In addition, Naticol¨Þ collagen inhibited wrinkle formation in Hs27 cells and SHK-I hairless mice exposed to UVB and restrained melanogenesis in 3-isobutyl-1-methylxanthine-induced B16F10 cells and UVB-irradiated SHK-I hairless mice. On the basis of these findings, we propose that ingestion of Naticol ¨Þ collagen might be valuable for preventing skin photoaging.
|
|
KEYWORD
|
|
fish collagen peptide, skin health, ultraviolet B
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|