KMID : 1160620230280030328
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Preventive Nutrition and Food Science 2023 Volume.28 No. 3 p.328 ~ p.334
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The Inhibitory Effects of Protaetia brevitarsis seulensis Larvae Extract on Human Platelet Aggregation and Glycoprotein IIb/IIIa Expression
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Kwon Hyuk-Woo
Rhee Man-Hee Shin Jung-Hae
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Abstract
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The white-spotted flower chafer, Protaetia brevitarsis seulensis, is used as a traditional remedy against liver cirrhosis, hepatitis, and hepatic cancer. In this study, we investigated if P. brevitarsis extract (PBE) inhibited platelet aggregation via integrin ¥áIIb/¥â3 regulation. We observed that PBE inhibited ¥áIIb/¥â3 activation by regulating the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate. Additionally, PBE affected phosphatidylinositol-3 kinase, Akt, SYK, glycogen synthase kinase-3¥á/¥â, cytosolic phospholipase A2, and p38 expression, which are signal transduction molecules expressed by platelets, and consequently suppressed ¥áIIb¥â3 activity and thromboxane A2 generation. Taken together, PBE showed strong antiplatelet effects and may be used to block thrombosis- and platelet-mediated cardiovascular diseases.
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KEYWORD
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cyclic nucleotides, glycoprotein IIb/IIIa, platelet aggregation, thrombosis
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