KMID : 1161420120150030288
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Journal of Medicinal Food 2012 Volume.15 No. 3 p.288 ~ p.298
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Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic ¥â Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice
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Sun Chong-De
Zhang Bo Zhang Jiu-Kai Xu Chang-Jie Wu Yu-Lian Li Xian Chen Kun-Song
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Abstract
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Chinese bayberry fruit is a rich source of anthocyanins, especially cyanidin-3-glucoside (C3G). The present study investigated the protective effects of C3G-rich bayberry fruit extract (CRBFE) against pancreatic ¥â cells against oxidative stress?induced injury as well as its hypoglycemic effect in diabetic mice. Bayberry extract from ¡°Biqi¡± was used for both in vitro and in vivo testing because of its high C3G content and high antioxidant capacity. Pretreatment of ¥â cells with CRBFE (containing 0.5?¥ìmol/L C3G) prevented cell death, increased cellular viability, and decreased mitochondrial reactive oxygen species production and cell necrosis induced by 800 or 1,200?¥ìmol/L H2O2. CRBFE dose-dependently up-regulated pancreatic duodenal homeobox 1 gene expression, contributing to increased insulin-like growth factor II gene transcript levels and insulin protein in INS-1 cells. In addition, administration of CRBFE (150?¥ìg of C3G/10?g of body weight twice per day) significantly reduced blood glucose in streptozotocin-induced diabetic ICR mice and increased the glucose tolerance in an oral glucose tolerance test (P<.05). Such results indicated that CRBFE might be useful in prevention and control of diabetes mellitus and diabetes-associated complications.
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KEYWORD
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anthocyanins, antioxidants, diabetes, fruit extract, oxidative stress
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