Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 1161520040080020117
Animal Cells and Systems
2004 Volume.8 No. 2 p.117 ~ p.123
Administration of agonistic anti-4-1 BB monoclonal antibody inhibits melanoma metastasis via IFN-¥ã production
Ju Seong-A

Lee Sang-Chul
Seok Moon-Hong
Kim Byung-Sam
Abstract
The purpose of this study was to analyze inhibitory effects of anti?4?1 BBmonoclonal antibody on melanoma metastasis. The 4?1 BB (CD137) T cell molecule is amember of the TNF receptor family and its activation by either 4?1 BB ligand or antibody induces T cell activation and growth. In the present study, administration of anti?4?1BB mAb induced inhibition of melanoma metastasis. Agonistic anti?4?1 BB mAb induced not only CD8+4?1BB+ T cells but also CD8+IFN?¥ã+ T cell population. In the presence of anti?CD3 antibody, lymphocytes produced high levels of IFN?¥ã and low levels of IL?4 in anti?4?1 BB mAb treated group. Exposure of melanoma cells to IFN?¥ã induced expression of MHC?I molecules. Thus, the increase in number of CD8+ T cells and enhanced MHC?I expression on B16F10 cells by augmented IFN?¥ã production in response to anti?4?1 BB mAb may result in suppression of tumor growth and metastasis.
KEYWORD
4?1 BB, IFN?¥ã
FullTexts / Linksout information
Listed journal information
SCI(E) ÇмúÁøÈïÀç´Ü(KCI)